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  Leptin Sensitivity
Dec 21, 2009
In much the same way that insulin sensitivity is diminished when high insulin levels and large spikes desensitize insulin receptors, a similar point applies to leptin sensitivity. Leptin once was thought to be the magic bullet for obesity; high leptin would produce a satiety signal and reduce food intake. But, it was later found that high leptin induced disappearance of leptin receptors and a loss of sensitivity. A similar fate to that of insulin.